Error in lmdb sync

Dear all

we are on solman 7.1 sp4 we are trying to add product system it shows system not add in LMDB the lmdb job cancelled SAP_LMDB_LDB_0000000001 can cancelled continuously it throws error

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it shows

HTTP destination LMDB_SyncDest1 is unreachable (http://IDxxx.ra.com:8001/sld/cimom (sld/active))

for this we have check rfc LMDB_SyncDest1 changed user and made it successful but still there is error

give me some solution

Regards